Publications

  • M. Trajkovic-Arsic, I. Heid, K. Steiger , A. Gupta, A. Fingerle, C. Wörner, N. Teichmann, S. Sengkwawoh-Lueong, P. Wenzel, A. J. Beer, I. Esposito, R. Braren & J. T. Siveke. Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma. Nature Scientific Reports. 2017 December 6; 7: 17038. doi:10.1038/s41598-017-16826-z
  • L Ciuffreda , A Del Curatolo,  I Falcone, F Conciatori, C Bazzichetto, F Cognetti, V Corbo, A Scarpa, M Milella. Lack of growth inhibitory synergism with combined MAPK/PI3K inhibition in preclinical models of pancreatic cancer. Annals of Oncology. 2017 November 1;  28(11): 2896–2898. doi.org/10.1093/annonc/mdx335
  • Ludwig Lausser, Robin Szekely, Lyn-Rouven Schirra, Hans A. Kestler. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Processing Letters. 2017 October 6; 1-18. doi 10.1007/s11063-017-9706-3
  • Paiella S, Malleo G, Cataldo I, Gasparini C, De Pastena M, De Marchi G, Marchegiani G, Rusev B, Scarpa A, Girelli R, Giardino A, Frigerio I, D'Onofrio M, Secchettin E, Bassi C, Salvia R. Radiofrequency ablation for locally advanced pancreatic cancer: SMAD4 analysis segregates a responsive subgroup of patients. Langenbeck's Archives of Surgery. 2017 October 5. doi: 10.1007/s00423-017-1627-0
  • Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, Chianchiano P, Brosens LA, Noë M, Offerhaus GJA, Yonescu R, Ning Y, Malleo G, Riva G, Piccoli P, Cataldo I, Capelli P, Zamboni G, Scarpa A, Wood LD. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. The Journal of Pathology. 2017 October 1; 243(2):148-154. doi: 10.1002/path.4941
  • Jan Eric Sträng , Rainer Schuler, Michael Kühl, Hans A. Kestler. Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis. Journal of Theoretical Biology. 2017 September 21; 429:82-94. doi.org/10.1016/j.jtbi.2017.06.027
  • MS Chattaragada, C Riganti, M Sassoe, M Principe, MM Santamorena, C Roux, C Curcio, A Evangelista, P Allavena, R Salvia, B Rusev, A Scarpa, P Cappello and F Novelli. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Oncogene. 2017 August 12; 1-13. doi:10.1038/onc.2017.358
  • Brajesh P. Kaistha, Anja Krattenmacher, Johannes Fredebohm, Harald Schmidt, Diana Behrens, Miriam Widder, Thilo Hackert, Oliver Strobel, Jörg D. Hoheisel, Thomas M. Gress and Malte Buchholz. The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators. Oncotarget. 2017 August 3; 8(39): 66215-66225. doi.org/10.18632/oncotarget.19882
  • Pea A, Yu J, Rezaee N, Luchini C, He J, Dal Molin M, Griffin JF, Fedor H, Fesharakizadeh S, Salvia R, Weiss MJ, Bassi C, Cameron JL, Zheng L, Scarpa A, Hruban RH, Lennon AM, Goggins M, Wolfgang CL, Wood LD. Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas. Annals of Surgery. 2017 July 1; 266(1):133-141. doi: 10.1097/SLA.0000000000001817
  • Gomez-Rubio P, Rosato V, Márquez M, Bosetti C, Molina-Montes E, Rava M, Piñero J, Michalski CW, Farré A, Molero X, Löhr M1, Ilzarbe L, Perea J, Greenhalf W, O'Rorke M, Tardón , Gress T, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Domínguez-Muñoz E, Gutiérrez-Sacristán A, Balsells J, Costello E, Guillén-Ponce C, Huang J, Iglesias M, Kleeff J, Kong B, Mora J, Murray L, O'Driscoll D, Peláez P, Poves I, Lawlor RT, Carrato A, Hidalgo M, Scarpa A, Sharp L, Furlong L, Real FX, La Vecchia C, Malats N; PanGenEU Study Investigators. A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk. Annals of Oncology. 2017 July 1; 28(7):1618-1624. doi: 10.1093/annonc/mdx167
  • Paiella S, Marchegiani G, Miotto M, Malpaga A, Impellizzeri H, Montagnini G, Pollini T, Nessi C, Butturini G, Capelli P, Posenato I, Scarpa A, D'Onofrio M, De Robertis R, Cingarlini S, Boninsegna L, Bassi C, Salvia R, Landoni L. Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity? Results from a Single Center Surgical Series. Neuroendocrinology. 2017 June 7. doi: 10.1159/000477849
  • Jun Wang, Laurent Dumartin, Andrea Mafficini, Pinar Ulug, Ajanthah Sangaralingam, Namaa Audi Alamiry, Tomasz P. Radon, Roberto Salvia, Rita T. Lawlor, Nicholas R. Lemoine, Aldo Scarpa, Claude Chelala & Tatjana Crnogorac-Jurcevic. Splice variants as novel targets in pancreatic ductal adenocarcinoma. Nature Scientific Reports. 2017 June 7; 7:2980. doi:10.1038/s41598-017-03354-z
  • Fassan M, Rusev B, Corbo V, Gasparini P, Luchini C, Vicentini C, Mafficini A, Paiella S, Salvia R, Cataldo I, Scarpa A3, Huebner K. Fhit down-regulation is an early event in pancreatic carcinogenesis. Virchows Archiv. 2017 June 1; 470(6):647-653. doi: 10.1007/s00428-017-2105-3
  • Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM, Amgheib A, Saif J, Perez M, Soriano J, Desco M, Gomez-Gaviro MV, Cusso L, Megias D, Aicher A, Heeschen C. The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Oncotarget. 2017 March 28. 8(13): 21609-25. doi 10.18632/oncotarget.15450
  • Kathrin A. Schmohl, Aayush Gupta, Geoffrey K. Grünwald, Marija Trajkovic-Arsic, Kathrin Klutz, Rickmer Braren, Markus Schwaiger, Peter J. Nelson, Manfred Ogris, Ernst Wagner, Jens T. Siveke and Christine Spitzweg. Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene. Oncotarget. 2017 March 23; 8:33393-33404. doi: 10.18632/oncotarget.16499
  • Milella M, Falcone I, Conciatori F, Matteoni S, Sacconi A, De Luca T, Bazzichetto C, Corbo V, Simbolo M, Sperduti I, Benfante A, Del Curatolo A, Cesta Incani U, Malusa F, Eramo A, Sette G, Scarpa A, Konopleva M, Andreeff M, McCubrey JA, Blandino G, Todaro M, Stassi G, De Maria R, Cognetti F, Del Bufalo D, Ciuffreda L. PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Nature Scientific Reports. 2017 February 21; 7:43013. doi: 10.1038/srep43013
  • Milella M, Falcone I, Conciatori F, Matteoni S, Sacconi A, De Luca T, Bazzichetto C, Corbo V, Simbolo M, Sperduti I, Benfante A, Del Curatolo A, Cesta Incani U, Malusa F, Eramo A, Sette G, Scarpa A, Konopleva M, Andreeff M, McCubrey JA, Blandino G, Todaro M, Stassi G, De Maria R, Cognetti F, Del Bufalo D, Ciuffreda L. PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Nature Scientific Reports. 2017 February 21; 7:43013. doi: 10.1038/srep43013
  • Milella M, Falcone I, Conciatori F, Matteoni S, Sacconi A, De Luca T, Bazzichetto C, Corbo V, Simbolo M, Sperduti I, Benfante A, Del Curatolo A, Cesta Incani U, Malusa F, Eramo A, Sette G, Scarpa A, Konopleva M, Andreeff M, McCubrey JA, Blandino G, Todaro M, Stassi G, De Maria R, Cognetti F, Del Bufalo D, Ciuffreda L. PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Nature Scientific Reports. 2017 February 21; 7:43013. doi: 10.1038/srep43013
  • Del Re M, Tiseo M, Bordi P, D'Incecco A, Camerini A, Petrini I, Lucchesi M, Inno A, Spada D, Vasile E, Citi V, Malpeli G, Testa E, Gori S, Falcone A, Amoroso D, Chella A, Cappuzzo F, Ardizzoni A, Scarpa A, Danesi R. Contribution of KRAS mutations and c.2369C > T (p.T790M) EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC: a study on circulating tumor DNA. Oncotarget. 2017 February 21; 8(8):13611-13619. doi: 10.18632/oncotarget.6957
  • Humphris JL, Patch AM, Nones K, Bailey PJ, Johns AL, McKay S, Chang DK, Miller DK, Pajic M, Kassahn KS, Quinn MC, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Stone A, Wilson PJ, Anderson M, Fink JL, Holmes O, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Mead RS, Xu Q2, Wu J, Pinese M, Cowley MJ, Jones MD, Nagrial AM, Chin VT, Chantrill LA12, Mawson A, Chou A, Scarlett CJ, Pinho AV, Rooman I, Giry-Laterriere M, Samra JS, Kench JG, Merrett ND, Toon CW, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, McKay CJ, Carter CR, Dickson EJ, Graham JS, Duthie F, Oien K, Hair J, Morton JP, Sansom OJ, Grützmann R, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL, Morgan RA, Lawlor RT, Rusev B, Corbo V, Salvia R, Cataldo I, Tortora G, Tempero MA; Australian Pancreatic Cancer Genome Initiative, Hofmann O, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Gill AJ, Pearson JV, Grimmond SM, Waddell N, Biankin AV. Hypermutation In Pancreatic Cancer. Gastroenterology. 2017 January 1; 152(1):68-74.e2. doi: 10.1053/j.gastro.2016.09.060
  • Jeremy L. Humphris, Ann-Marie Patch et al.. Hypermutation In Pancreatic Cancer. Gastroenterology. 2017 January; 152: 1 , 68-74.e2. doi: 10.1053/j.gastro.2016.09.060
  • Pouria Jandaghi, Hamed S. Najafabadi, Andrea S. Bauer, Andreas I. Papadakis, Matteo Fassan, Anita Hall, Anie Monast, Magnus von Knebel Doeberitz, John P. Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Bence Sipos, Daniel Auld, Mark Lathrop, Morag Park, Markus W. Büchler, Oliver Strobel, Thilo Hackert, Nathalia A. Giese, George Zogopoulos, Veena Sangwan, Sidong Huang, Yasser Riazalhosseini, Jörg D. Hoheisel. Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice. Gastroenterology. 2016 December; 151:6, 1218–1231. doi: 10.1053/j.gastro.2016.08.040
  • Stefano Andrianello, Giovanni Marchegiani, Giuseppe Malleo, Borislav Chavdarov Rusev, Aldo Scarpa, Deborah Bonamini, Laura Maggino, Claudio Bassi, Roberto Salvia. Over 700 Whipples for Pancreaticobiliary Malignancies: Postoperative Morbidity Is an Additional Negative Prognostic Factor for Distal Bile Duct Cancer. J Gastrointest Surg. 2016 November 23. doi:10.1007/s11605-016-3328-3
  • Julian Schwab, Andre Burkovski, Lea Siegle, Christoph Müssel and Hans A. Kestler. ViSiBooL - visualization and simulation of Boolean networks with temporal constraints. Bioinformatics. 2016 October 22. doi: 10.1093/bioinformatics/btw661

  • Taudien S., Lausser L., Giamarellos-Bourboulis E.J., Sponholz C., Schöneweck F., Felder M., Schirra L.R., Schmid F., Gogos C., Groth S., Petersen B.S., Franke A., Lieb W., Huse K., Zipfel P.F., Kurzai O., Moepps B., Gierschik P., Bauer M., Scherag A., Kestler H.A., Platzer M.. Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EbioMedicine. 2016 Oct 12; 12:227–238. doi: 10.1016/j.ebiom.2016.08.037
  • Gunnar Völkel, Sebastian Wiese, Karlheinz Holzmann, Johann M. Kraus, Fabian Schneider, Matthias Görlach, Hans A. Kestler. TraqBio - Flexible Progress Tracking for Core Unit Projects. PLOS ONE. 2016 September 27. doi: 10.1371/journal.pone.0162857

  • Irina Heid, Katja Steiger, Marija Trajkovic-Arsic, Marcus Settles, Manuela R Eßwein, Mert Erkan, Jorg Kleeff, Carsten Jäger, Helmut Friess, Bernhard Haller, Andreas Steingötter, Roland M Schmid, Markus Schwaiger, Ernst J Rummeny, Irene Esposito, Jens T Siveke and Rickmer Braren. Co-clinical assessment of tumor cellularity in pancreatic cancer. Clinical Cancer Research. 2016 September 23. doi: 10.1158/1078-0432.CCR-15-2432
  • Pietro Carotenuto, Matteo Fassan, Rosantony Pandolfo, Andrea Lampis, Caterina Vicentini, Luciano Cascione, Viola Paulus-Hock, Luke Boulter, Rachel Guest, Luca Quagliata, Jens Claus Hahne, Rachel Ridgway, Tam Jamieson, Dimitris Athineos, Angelo Veronese, Rosa Visone, Claudio Murgia, Giulia Ferrari, Vincenza Guzzardo, Thomas Ronald Jeffry Evans, Martin MacLeod, Gui Ji Feng, Trevor Dale, Massimo Negrini, Stuart J Forbes, Luigi Terracciano, Aldo Scarpa, Tushar Patel, Nicola Valeri, Paul Workman, Owen Sansom, Chiara Braconi. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. GI cancer. 2016 September 12. doi:10.1136/gutjnl-2016-312278
  • Lyn-Rouven Schirra, Florian Schmid et al.. Interpretable Classifiers in Precision Medicine: Feature Selection and Multi-class Categorization. Lecture Notes in Computer Science. 2016 September 11; 9896:105-116. doi: 10.1007/978-3-319-46182-3_9

  • Mafficini, Andrea; Amato, Eliana; Cataldo, Ivana et al.. Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations. Annals of Surgery. 2016 September.  doi: 10.1097/SLA.0000000000001999

  • Zagorac S, Alcala S, Fernandez Bayon G, Bou Kheir T, Schoenhals M, González-Neira A, Fernandez Fraga M, Aicher A, Heeschen C, Sainz B Jr. DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster. Cancer Research. 2016 August 1; 76:15, 4546-58. doi: 10.1158/0008-5472.CAN-15-3268
  • Giovanni Marchegiani, Stefano Andrianello, Marta Massignani, Giuseppe Malleo, Laura Maggino, Salvatore Paiella, Cristina R. Ferrone, Claudio Luchini, Aldo Scarpa, Paola Capelli, Mari Mino-Kenudson, Keith D. Lillemoe, Claudio Bassi, Carlos Fernàndez-del Castillo, Roberto Salvia. Solid pseudopapillary tumors of the pancreas: Specific pathological features predict the likelihood of postoperative recurrence. Journal of Surgical Oncology. 2016 July 29; 114:5, 597–601. doi: 10.1002/jso.24380
  • Pea Antonio, Yu Jun, Rezaee Neda, Luchini Claudio, He Jin, Dal Molin Marco, Griffin James F, et al. 2016. Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas. Annals of Surgery. 2016 July 18. doi:10.1097/SLA.0000000000001817
  • Giovanni Marchegiani, Stefano Andrianello, Giuseppe Malleo, Lucia De Gregorio, Aldo Scarpa, Mari Mino-Kenudson, Laura Maggino, Cristina R Ferrone, Keith D Lillemoe, Claudio Bassi, Carlos Fernàndez-Del Castillo, Roberto Salvia. Does Size Matter in Pancreatic Cancer?: Reappraisal of Tumour Dimension as a Predictor of Outcome Beyond the TNM. Annals of Surgery. 2016 June 17. doi: 10.1097/SLA.0000000000001837
  • Florian Schmid, Matthias Schmid, Christoph Müssel, J. Eric Sträng, Christian Buske, Lars Bullinger, Johann M. Kraus and Hans A. Kestler. GiANT: Gene set uncertainty in enrichment analysis. Bioinformatics. 2016 June 15; 32:12, 1891-1894. doi: 10.1093/bioinformatics/btw030

  • Patricia Sancho, David Barneda and Christopher Heeschen. Hallmarks of cancer stem cell metabolism. Br J Cancer. 2016 May 24; 114: 1305-1312. doi:10.1038/bjc.2016.152
  • Andrea Ruzzenente, Matteo Fassan, Simone Conci, Michele Simbolo, Rita T. Lawlor, Corrado Pedrazzani, Paola Capelli, Mirko D’Onofrio, Calogero Iacono, Aldo Scarpa, Alfredo Guglielmi. Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients. Annals of Surgical Oncology. 2016 May 23; 23:1699. doi: 10.1245/s10434-015-5046-6
  • Clara Lubeseder-Martellato, Ana Hidalgo-Sastre, Carolin Hartmann, Katharina Alexandrow, Zahra Kamyabi-Moghaddam, Bence Sipos, Matthias Wirth, Florian Neff, Maximilian Reichert, Irina Heid, Günter Schneider, Rickmer Braren, Roland M. Schmid, Jens T. Siveke. Membranous CD24 drives the epithelial phenotype of pancreatic cancer. Oncotarget. 2016 May 17; 7:31, 49156-68. doi: 10.18632/oncotarget.9402
  • Barbara M. Grüner, Isabel Winkelmann, Annette Feuchtinger, Na Sun, Benjamin Balluff, Nicole Teichmann, Alexander Herner, Evdokia Kalideris, Katja Steiger, Rickmer Braren, Michaela Aichler, Irene Esposito, Roland M. Schmid, Axel Walch and Jens T. Siveke. Modeling Therapy Response and Spatial Tissue Distribution of Erlotinib in Pancreatic Cancer. Molecular Cancer Therapeutics. 2016 May; 15:5, 1145–52. doi: 10.1158/1535-7163.MCT-15-0165
  • Heeschen C, Sancho P. More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells. Mol Cell Oncol. 2016 March 16; 3:2. doi: 10.1080/23723556.2015.1105353
  • Ludwig Lausser, Florian Schmid, Matthias Platzer, Mikko J. Sillanpää and Hans A. Kestler. Semantic multi-classifier systems for the analysis of gene expression profiles. Archives of Data Science Series A. 2016 March 9; 1:1. (No doi available)

  • Peter Bailey, David K. Chang, Katia Nones, Amber L. Johns, Ann-Marie Patch, Marie-Claude Gingras, David K. Miller, Angelika N. Christ, Tim J. C. Bruxner, Michael C. Quinn, Craig Nourse, L. Charles Murtaugh, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Ehsan Nourbakhsh, Shivangi Wani, Lynn Fink, Oliver Holmes, Venessa Chin, Matthew J. Anderson, Stephen Kazakoff, Conrad Leonard, Felicity Newell, Nick Waddell et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature. 2016 March 3; 531: 47-52. doi:10.1038/nature16965
  • Dahlhaus M., Burkovski A., Hertwig F., Mussel C., Volland R., Fischer M., Debatin K.M., Kestler H.A., Beltinger C.. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma. Cancer Letters. 2016 February 1; 371:1, 79-89. doi: 10.1016/j.canlet.2015.11.025

  • Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo, Giorgio Malpeli. RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes. BMC Cancer. 2016 January 12; 16:11. doi: 10.1186/s12885-016-2048-0
  • Andrea Mafficini, Michele Simbolo, Alice Parisi, Borislav Rusev, Claudio Luchini, Ivana Cataldo, Elena Piazzola, Nicola Sperandio, Giona Turri, Massimo Franchi, Giampaolo Tortora, Chiara Bovo, Rita T. Lawlor, Aldo Scarpa. BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing. Oncotarget. 2016 January 7; 7:2, 1076-1083. doi: 10.18632/oncotarget.6834
  • Simbolo M, Fassan M, Mafficini A, Lawlor RT, Ruzzenente A, Scarpa A. New genomic landscapes and therapeutic targets for biliary tract cancers. Front Biosci (Landmark Ed). 2016 Jan 1; 21:707-718. https://www.ncbi.nlm.nih.gov/pubmed/26709801
  • Juliana Andrici, Benjamin Goeppert, Loretta Sioson, Adele Clarkson, Marcus Renner, Albrecht Stenzinger, Michael Tayao, Nicole Watson, Mahtab Farzin, Christopher W. Toon, Ross C. Smith, Anubhav Mittal, Jaswinder S. Samra, Thomas J. Hugh, Angela Chou, Rita T. Lawlor, Wilko Weichert, Peter Schirmacher, Nicola Sperandio, Andrea Ruzzenente, Aldo Scarpa, Anthony J. Gill. Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma. Medicine. 2016 January; 95:2. doi: 10.1097/MD.0000000000002491
  • B. P. Kaistha, H. Lorenz, H. Schmidt, B. Sipos, M. Pawlak, B. Gierke, R. Kreider, B. Lankat-Buttgereit, M. Sauer, L. Fiedler, A. Krattenmacher, B. Geisel, J. M. Kraus, K. K. Frese, S. Kelkenberg, N. A. Giese, H. A. Kestler, T. M. Gress, M. Buchholz. PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways. Cancer Research. 2015 December 15; 76(1): 1–12. doi: 10.1158/0008-5472.CAN-15-0216
  • Diana Behrens, Diana Anders, Cora Hallas, Jessica Pahle, Iduna Fichtner. In vivo models of pancreatic cancer for translational medicine. Mol Cancer Ther. 2015 December; 14:12 Suppl 2. doi: 10.1158/1535-7163.TARG-15-A100
  • Christoph Müssel, Florian Schmid, Tamara J. Blätte, Martin Hopfensitz, Ludwig Lausser3 and Hans A. Kestler. BiTrinA—multiscale binarization and trinarization with quality analysis. Bioinformatics. 2015 November 4; 1-4. doi: 10.1093/bioinformatics/btv591

  • Christoph Müssel , Florian Schmid , Tamara J. Blätte , Martin Hopfensitz , Ludwig Lausser , Hans A. Kestler. BiTrinA—multiscale binarization and trinarization with quality analysis. Bioinformatics. 2015 Oct 14. pii: btv591. [Epub ahead of print].
  • Pawel K Mazur et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015 Oct;21(10):1163-71. doi: 10.1038/nm.3952
  • Rickmer F Braren , Jens T Siveke. Next-generation metabolic imaging in pancreatic cancer. Gut. 2015 Oct. 13. doi:10.1136/gutjnl-2015-310518
  • Deepak Raj , Alexandra Aicher , Christopher Heeschen. Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation. Stem Cells. 2015 Oct;33(10):2893-902. doi: 10.1002/stem.2114
  • Michele Cioffi , Mireia Vallespinos-Serrano , Sara M. Trabulo , Pablo Jose Fernandez-Marcos , Ashley N. Firment , Berta N. Vazquez , Catarina R. Vieira , Francesca Mulero , Juan A. Camara , Ultan P. Cronin , Manuel Perez , Joaquim Soriano , Beatriz G. Galvez , Alvaro Castells-Garcia , Verena Haage , Deepak Raj , Diego Megias , Stephan Hahn , Lourdes Serrano , Anne Moon , Alexandra Aicher , Christopher Heeschen. MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3. Cell Rep. 2015 Sep 8;12(10):1594-605. doi: 10.1016/j.celrep.2015.08.006
  • Melanie Grieb , Andre Burkovski , J. Eric Sträng , Johann M. Kraus , Alexander Groß , Günther Palm , Michael Kühl , Hans A. Kestler. Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty. PLoS One. 2015 Jul 24. doi: 10.1371/journal.pone.0131832
  • Nabendu Pore , Sanjoo Jalla , Zheng Liu , Brandon Higgs , Claudio Sorio , Aldo Scarpa , Robert Hollingsworth , David A. Tice , Emil Michelotti. In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors. Neoplasia. 2015 Jun;17(6):473-80. doi: 10.1016/j.neo.2015.05.001
  • Ming-Hsin Yang, Ahmet Imrali1, Christopher Heeschen. Circulating cancer stem cells: the importance to select. Chin J Cancer Res. 2015 Oct;27(5):437-49. doi: 10.3978/j.issn.1000-9604.2015.04.08
  • G. Volkel , L. Lausser , F. Schmid , J. M. Kraus , H. A. Kestler. Sputnik: ad hoc distributed computation. Bioinformatics. 2015 Apr 15;31(8):1298-301. doi: 10.1093/bioinformatics/btu818
  • Malte Buchholz , Tatjana Honstein , Sandra Kirchhoff , Ramona Kreider , Harald Schmidt , Bence Sipos , Thomas M. Gress. A Multistep High-Content Screening Approach to Identify Novel Functionally Relevant Target Genes in Pancreatic Cancer. PLoS One. 2015 Apr 7;10(4):e0122946. doi: 10.1371/journal.pone.0122946
  • K. Hein , G. Mittler , W. Cizelsky , M. Kuhl , F. Ferrante , R. Liefke , I. M. Berger , S. Just , J. E. Strang , H. A. Kestler , F. Oswald , T. Borggrefe. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal. 2015 Mar 24;8(369):ra30. doi: 10.1126/scisignal.2005892
  • Maria Scardoni , Emanuele Vittoria , Marco Volante , Borislav Rusev , Samantha Bersani , Andrea Mafficini , Marisa Gottardi , Valeria Giandomenico , Giuseppe Malleo , Giovanni Butturini , Sara Cingarlini , Matteo Fassan , Aldo Scarpa. Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components. Neuroendocrinology. 2014;100(4):310-6. doi: 10.1159/000369071
  • Enza Lonardo , Michele Cioffi , Patricia Sancho , Shanthini Crusz , Christopher Heeschen. Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies. J Vis Exp. 2015 Jun 20;(100):e52801. doi: 10.3791/52801
  • B. Sainz , B. Martin , M. Tatari , C. Heeschen , S. Guerra. ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells. Cancer Research. 2014 Dec 15; 74(24):7309-7320. doi: 10.1158/0008-5472.CAN-14-1354
  • F. Schmid, L. Lausser. Linear Contrast Classifiers in High-Dimensional Spaces. Lecture Notes in Computer Science. 2014 Oct 6; 8774:141-152.
  • I. Miranda-Lorenzo , J. Dorado , E. Lonardo , S. Alcala , A. G. Serrano , J.r Clausell-Tormos , M. Cioffi , Diego Megias , S. Zagorac , A. Balic , M. Hidalgo , M. Erkan , J. Kleeff , A. Scarpa , B. Sainz , C. Heeschen. Intracellular autofluorescence: a biomarker for epithelial cancer stem cells. Nature Methods. 2014 Sept. 28; 11(11):1161-1169. doi: 10.1038/nmeth.3112
  • A. Mafficini , E. Amato , M. Fassan , M. Simbolo , D. Antonello , C. Vicentini , M. Scardoni , S. Bersani , M. Gottardi , B. Rusev , G. Malpeli , V. Corbo , S. Barbi , K. O. Sikora , R. T. Lawlor , G. Tortora , A. Scarpa. Reporting Tumor Molecular Heterogeneity in Histopathological Diagnosis. PLoS One. 2014 Aug 15; 9(8): e104979. doi: 10.1371/journal.pone.0104979
  • A. Balic , M. D. Sorensen , S. M. Trabulo , B. Sainz , M. Cioffi , C. R. Vieira , I. Miranda-Lorenzo , M. Hidalgo , J. Kleeff , M. Erkan , C. Heeschen. Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling. Molecular Cancer Therapeutics. 2014 July 1; 13(7):1758-1771. doi: 10.1158/1535-7163.MCT-13-0948
  • M. Simbolo. Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups. Oncotarget. 2014 May 15; 5(9):28539-2852. DOI: 10.18632/oncotarget.1943
  • J. Clausell-Tormos, M. M. Azevedo, I. Miranda-Lorenzo, C. R. Vieira, Y. Sanchez-Ripoll, D. Megias, C.Heeschen. Nanovolume well array chip for large-scale propagation and high-resolution analysis of individual cancer stem cells. 2014 March 31; 5(2):192. doi: 10.4172/2157-7439.1000192
  • M. Scardoni , E. Vittoria , M. Volante , B. Rusev , S. Bersani , A. Mafficini , M. Gottardi , V. Giandomenico , G. Malleo , G. Butturini , S. Cingarlini , M. Fassan , A. Scarpa. Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: Targeted Next Generation Sequencing Suggests a Monoclonal Origin of the Two Components. Neuroendocrinology. 2014 Jan 1; doi: 10.1159/000369071

     

[^]